An interesting study, examining the association of BCG vaccination and risk of COVID-19 deaths using country level data. Authors make a compelling case that there is an association using data from a large number of countries.
Such studies have potential for ecological fallacy – however, there is underlying biological plausibility and further, as we are collecting data on these cases, knowing about patients who had BCG vaccination versus those who did not may help to solidify the evidence in support of BCG. In other words, the evidence in not solid but need further study.
Indeed, clinical trial examining the role of BCG in stimulating immunity and generating resistance is ongoing Australia where they are planning to enroll approximately 4,000 healthcare workers at hospitals across Australia.
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