VPREB3 protein is the human homolog of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-cell differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. This protein associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of the protein is not known, but it may contribute to mu chain transport in pre-B cells.
This protein doesn’t appear to be detectable in platelet proteome studies but its transcript is present in platelets (detected by both RNA-seq and microarray studies). Its role in platelet biology remains unclear. Even interesting is that the RNA-seq experiment found a much lower expression level than the microarray experiment (0.15 RPKM vs. 27250 MFI). Perhaps the level of gene expression is quite variable from person to person.
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