While antibiotics are essential for treatment of bacterial infection, an increasingly recognized adverse effect of antibiotic use is alteration in gut microbiome. The altered gut microbiome can result in several acute and long-term unhealthy effects. This small clinical trial tests the use of an adsorbent to to mitigate the effects of antibiotics on gut microbiome. Investigators found, using the shotgun quantitative metagenomics, that the richness and composition of the intestinal microbiota were largely preserved in subjects using antibiotics when co-treated with DAV132 (the adsorbent used in this study). This is an important study, and if the adsorbent is effective without compromising the antibiotic availability in blood, may be extremely useful in clinical medicine.
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